2015 Fiscal Year Final Research Report
Construction of new therapeutic strategy and elucidation of pathogenic mechanism through chromatin remodeling factor of ovarian clear cell adenocarcinoma
| Project/Area Number |
25861515
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
Uekawa Atsushi 聖マリアンナ医科大学, 医学部, 研究技術員 (60534253)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 卵巣明細胞腺癌 |
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| Outline of Final Research Achievements |
ARID1A encodes BAF250a, a key component of the SWI-SNF chromatin remodeling complex. ARID1A mutations are observed in various tumors, including ovarian clear cell and endometrioid carcinomas, endometrial, and breast carcinomas. In this study, we demonstrated that ARID1A negatively regulates cellular proliferation. This negative regulation is achieved through molecular collaboration between ARID1A and p53, to regulate tumor-inhibiting p53-downstream target genes such as CDKN1A (p21).
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| Free Research Field |
婦人科腫瘍学
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