2014 Fiscal Year Final Research Report
Function of Epstein-Barr virus-encoded microRNAs in nasal NK/T-cell lymphoma
| Project/Area Number |
25861520
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 鼻性NK/T細胞リンパ腫 / Epstein-Barr virus / microRNA / ebv-miR-BART22 |
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| Outline of Final Research Achievements |
Nasal natural killer/T cell lymphoma (NNKTL) is Epstein-Barr virus (EBV)-associated malignancy and characterized by a poor prognosis. In the present study, microarray analysis showed that ebv-miR-BART22 was highly expressed in NNKL cell lines. We found that ebv-miR-BART22 could regulate PCDC4 expression. Moreover, we showed that knockdown of ebv-miR-BAR22 induced apoptosis in NNKTL cells. These data suggest that ebv-miR-BART22 implicates in cell proliferation regulating PDCD4 expression in NNKTL.
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| Free Research Field |
医歯薬学
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