2014 Fiscal Year Final Research Report
Impact of ORMDL3 gene expression in allergic rhinitis
| Project/Area Number |
25861539
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Fukui |
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Principal Investigator |
TOMITA Kaori 福井大学, 医学部, 特別研究員 (30444227)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | ORMDL3 / アレルギー性鼻炎 / 鼻ポリープ |
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| Outline of Final Research Achievements |
The aim of this study is to investigate how ORMDL3, asthma susceptible gene, involve in the development of allergic rhinitis.In this study, we established the protocol for isolation of the inflammatory cells from peripheral blood, and we show that the isolated inflammatory cells show the same allergic inflammatory response as inside the body.
We show high ORMDL3 expression level in nasal mucosa of eosinophilic chronic rhinitis patients. Our findings indicate that ORMDL3 may be involved in the development of the allergic disease in humans.
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| Free Research Field |
アレルギー性鼻炎
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