2015 Fiscal Year Final Research Report
Systematic analysis of the glutamine-gulutamate cycle in the mice inner ear
| Project/Area Number |
25861542
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Research Collaborator |
USAMI Shin-ichi 信州大学, 学術研究院医学系, 教授 (10184996)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 難聴 / 遺伝子 / グルタミン酸 |
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| Outline of Final Research Achievements |
Glutamate has been implicated in signal transmission between inner hair cells and afferent fibers of the organ of Corti. The inner hair cells are enriched in glutamate and the postsynaptic membranes express AMPA glutamate receptors. However, it is not known whether inner hair cells contain a mechanism for glutamate replenishment. Such a mechanism must be in place to sustain glutamate neurotransmission. We performed RT-PCR and immunofluorescence analysis of system N transporter. We also performed genetic analysis of Japanese sensorineural hearing loss patients and find one family with SLC17A8 mutation.
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| Free Research Field |
耳鼻咽喉科学
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