2015 Fiscal Year Final Research Report
Role of IL-31 in the pathogenesis of allergic rhinitis
| Project/Area Number |
25861563
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | IL-31 / スギ花粉症 / リンパ球 / IL-33 / IL-2 / 自然リンパ球 / CD127 / IL-5 |
|---|
| Outline of Final Research Achievements |
66% of peripheral blood mononuclear cells (PBMCs) from patients with Japanese cedar pollinosis produced IL-31 in response to Cry j 1, the major allergen molecule in Japanese cedar pollen. Symptom score and QOL score were significantly higher in patients with positive IL-31 production than those with negative production. IL-31 production by PMBCs were significantly increased following the exposure to IL-2 and IL-33. On the other hand, no induction of IL-31 production was seen in innate lymphoid cells in PBMCs. These results suggest that main IL-31 producing cell in PBMCs was CD4 positive T cells, and the cells are involved in the exacerbation of allergic rhinitis.
|
| Free Research Field |
耳鼻咽喉科学、アレルギー学
|
