2015 Fiscal Year Final Research Report
Screening for a protective effect in cochlear hair cells using candidate drugs in the zebrafish lateral line
| Project/Area Number |
25861564
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ゼブラフィッシュ / 側線器有毛細胞 / 内耳障害 / 内耳保護 |
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| Outline of Final Research Achievements |
In this study, we investigated the protective effect of 18 supplements,and 8 herbal medicine against hair cell degeneration induced by neomycin using zebrafish lateral hair cells damage model. We found that 3 supplements and all of 8 herbal medicine protects sensory hair cells against neomycin-induced death in zebrafish lateral cell lines. In addition, we confirmed the protective effect of screened drugs against noise-induced hearing loss in guinea pigs. These results show that screened drugs can be useful as a protective drug in the inner ear.
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| Free Research Field |
内耳基礎研究
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