Functional Analysis of c-Cbl Interacting Protein of 85 kDa in Head and Neck Squamous Cell Carcinoma.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861567
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: National Hospital Organization, Kyushu Cancer Center (2014-2015); Kyushu University (2013)
• Principal Investigator: Wakasaki Takahiro 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, その他 (10608871)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: CIN85 / Head and Neck / Squamous Cell Carcinoma

Outline of Final Research Achievements

In this study, it was suggested that CIN85 went through the PI3K/Akt pathway as well as Ras/MAPK pathway, which contributes to a tumor progress in head and neck squamous cell carcinoma (HNSCC).
I showed that CIN85 right related to elevating invasion ability other than increasing proliferative ability in the HNSCC cell line in this study. However, I was not able to prove a meaningful relationship between CIN85 and EMT-related genes. According to both gene expression analyses and western blotting analyses of HNSCC cell lines (control v. s. CIN85 knock down), it is elucidated the participation of the PI3K / Akt pathway. CIN85 is an adapter gene, and the joint molecule diverges into many branches. CIN85 may contribute to the phenotype of cancer by various pathways.

Free Research Field

Head and Neck Carcinoma