2015 Fiscal Year Final Research Report
Functional Analysis of c-Cbl Interacting Protein of 85 kDa in Head and Neck Squamous Cell Carcinoma.
Project/Area Number |
25861567
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Otorhinolaryngology
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Research Institution | National Hospital Organization, Kyushu Cancer Center (2014-2015) Kyushu University (2013) |
Principal Investigator |
Wakasaki Takahiro 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, その他 (10608871)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | CIN85 / Head and Neck / Squamous Cell Carcinoma |
Outline of Final Research Achievements |
In this study, it was suggested that CIN85 went through the PI3K/Akt pathway as well as Ras/MAPK pathway, which contributes to a tumor progress in head and neck squamous cell carcinoma (HNSCC). I showed that CIN85 right related to elevating invasion ability other than increasing proliferative ability in the HNSCC cell line in this study. However, I was not able to prove a meaningful relationship between CIN85 and EMT-related genes. According to both gene expression analyses and western blotting analyses of HNSCC cell lines (control v. s. CIN85 knock down), it is elucidated the participation of the PI3K / Akt pathway. CIN85 is an adapter gene, and the joint molecule diverges into many branches. CIN85 may contribute to the phenotype of cancer by various pathways.
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Free Research Field |
Head and Neck Carcinoma
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