2015 Fiscal Year Final Research Report
New therapuitic strategy based on functional analysis of antigen presenting cell in the Lymphoepithelium of Pediatric Adenoids via druo delivary system.
| Project/Area Number |
25861574
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 上皮細胞 / RSV / 宿主免疫応答 |
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| Outline of Final Research Achievements |
Nose- or nasopharynx-associated lymphoid tissue (NALT) has a unique role that is distinct from that of other lymphoid tissues. During upper airway mucosal immune response, NALT induces a variety of responses, including cytokine and chemokine production and innate immune response, to establish acquired immunity. NALT consists of epithelial cells, epithelium-associated lymphoid tissues such as IgA-committed B cells, innate lymphocytes, T helper cells and dendritic cells. Intranasal immunization has recently been shown to effectively induce a proactive immune response in the local mucosa in addition to a systemic immune response. We provide evidence suggesting that upper airway epitheium as a component of NALT in children may play an important role in inducing innate immunity following viral infection.
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| Free Research Field |
粘膜免疫学
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