2014 Fiscal Year Final Research Report
Analysis of calcium signaling in DFNP93 mutation in the hair cells
| Project/Area Number |
25861578
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Nagoya City University |
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Principal Investigator |
INAGAKI Akira 名古屋市立大学, 医学(系)研究科(研究院), 助教 (70405166)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 耳鼻咽喉科 / 耳科学 / カルシウム結合タンパク / CaBP |
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| Outline of Final Research Achievements |
The distribution of Calcium binding protein 2 (CaBP2) was examined by immunohistochemistry by using rabbit polyclonal antibody against mouse CaBP2. The immunoreactivities were observed in the cytosols of inner hair cells, which was proved by the co-localization with myo7a, a inner hair cell- cytosolic marker. A moderate signal was observed in the cytosols of outer hair cells, but more intense signals were seen in the membranous lesion of outer hair cells. Also supporting cells such as pillar cells, were weakly stained.
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| Free Research Field |
耳科学
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