Establishment and analysis of experimental model of sarcoid uveitis using propionibacterium acnes.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861620
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MIYANAGA Masaru 東京医科歯科大学, 医学部附属病院, 非常勤講師 (30599600)
• Co-Investigator(Renkei-kenkyūsha): TAKASE Hiroshi 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (20451940)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: サルコイドーシス / ぶどう膜炎 / アクネ菌

Outline of Final Research Achievements

Sarcoidosis is an inflammatory disorder of unknown etiology, featured by granuloma formation in the eye, lung, and skin. Recent studies revealed that propionibacterium acnes, normal bacterial flora in the skin, is present in the granuloma, and it is implicated that immune reaction against P. acnes is the cause of sarcoidosis. In this study, we attempted to establish P. acnes infected mice by tail vein injection of viable P. acnes, and to establish animal model of granulomatous inflammation by inducing cellular immunity against P. acnes by active immunization. As a result, most of the experimental mice showed granuloma formation and positive signal against P. acnes in the granuloma by immunohistochemical analysis. However, there was no granuloma or inflammation in the eye.

Free Research Field

眼科学