2014 Fiscal Year Final Research Report
Suppression of the choroidal neovascularization by Thioredoxin
| Project/Area Number |
25861633
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
|
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| Research Institution | Shimane University |
|---|
Principal Investigator |
|
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | HpODE / CNV / TRX |
|---|
| Outline of Final Research Achievements |
The subretinal injection of the lipid hydroperoxide 13(S)-Hydroperoxy-9Z,11E-octadecadienoic acid (HpODE) induced the choroidal neovascularization (CNV) in rat eyes. The incidence of HpODE-induced CNV was reduced in rats treated with thioredoxin (TRX) compared with the control. The concentration of vascular endothelial growth factor (VEGF) was lower in the tissue fluid of rat eyes treated with TRX compared with the control, so TRX may suppress the CNV by reducing the production of VEGF in the rat eyes.
|
| Free Research Field |
眼科学
|
