2015 Fiscal Year Final Research Report
Involvement of programmed necrosis in age-related macular degeneration
| Project/Area Number |
25861637
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Research Collaborator |
VAVVAS Demetrios
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 加齢黄斑変性 / 能動的ネクローシス / RIPキナーゼ |
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| Outline of Final Research Achievements |
Double strand RNA (dsRNA) accumulates in the drusen of AMD patient eyes, and has been shown to be implicated in the development of the disease. Here we investigated the mechanisms by which dsRNA causes retinal degeneration in mice. Subretinal injection of dsRNA caused both apoptotic and necrotic photoreceptor cell death, while it mediated necrosis of the retinal pigment epithelium (RPE). These necrotic changes were substantially suppressed by RIP kinase inhibition. Thus, RIP kinase-mediated necrosis is crucial in dsRNA-induced retinal degeneration, and RIP kinase may be a novel therapeutic target for retinal degenerative diseases such as AMD.
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| Free Research Field |
眼科学
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