Factors involved in exacerbation of diabetic retinopathy

2016 Fiscal Year Final Research Report

• Project/Area Number: 25861638
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Nagasaki University
• Principal Investigator: MATSUMOTO Makiko 長崎大学, 医歯薬学総合研究科(医学系), 助教 (70437903)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: VEGF / 糖尿病黄斑浮腫 / 網膜中心静脈閉塞症 / 血流

Outline of Final Research Achievements

Our initial objective was the development of a next-line treatment of anti-vascular endothelial growth factor (VEGF) drugs for the treatment of intraocular proliferative diseases including diabetic retinopathy. For this purpose it is necessary to clarify the pathology of these diseases. We observed the retinal blood flow changes against diabetic macular edema in anti-VEGF drugs, subcutaneous steroid injection and surgery, respectively. In addition, changes in blood flow were observed when macular edema associated with central retinal vein occlusion (CRVO), which is also an intraocular proliferative disease, was treated with an anti-VEGF drug.From these results, we tried to elucidate the pathology.
We reported the results at meeting both in Japan and abroad, and reported on the paper about CRVO.

Free Research Field

眼科学