2015 Fiscal Year Final Research Report
Manufacture of DMEK injector
Project/Area Number |
25861653
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Ophthalmology
|
Research Institution | Juntendo University |
Principal Investigator |
|
Research Collaborator |
NAKATANI Satoru 順天堂大学, 医学部, 准教授 (80343490)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 角膜内皮移植 / DMEK / 培養角膜内皮細胞 |
Outline of Final Research Achievements |
Our purpose was to develop and assess DMEK specific injector to reduce corneal endothelial damage with cultured corneal endothelial cell. DMEK injector, with which corneal endothelial cell was reduced 10% in vitro and 20% ex vivo, was used in corneal transplantation in bullous rabbit model. Protein expression of functional marker in cultured corneal cell was reinforce after transplantation. DMEK surgery was performed with injector, in result of non complication. Our results of using DMEK injector with cultured corneal endothelial sheet may help not only for donor graft, but for cultured corneal endothelial cell or iPS cell in clinical application.
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Free Research Field |
角膜内皮
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