2015 Fiscal Year Final Research Report
Visual function and Pathogenesis of Experimental Optic Neuritis
| Project/Area Number |
25861654
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 神経眼科 / 視神経炎 / 視神経脊髄炎 / neurofascin / ago-glial junction |
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| Outline of Final Research Achievements |
1.There is a possibility that functional axonal ｄｙsfunction precedes, pathological axonal damage in experimental optic neuritis. 2. Serum neurofascin may be a byproduct of axo-glial junction damage in patients with optic neuritis in neuromyelitis optica. 3. Anti-aquaporin-4 (AQP-4) antibody exists in the aqueous humor of AQP-4 positive optic neuritis patients. Therefore, there is a possibility that inner retinal layer thinning is a result of direct retinal damage.
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| Free Research Field |
眼科学
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