2014 Fiscal Year Final Research Report
New treatment guideline of the corneal transplant based on tear cytokine.
| Project/Area Number |
25861655
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIMAZAKI Jun 東京歯科大学市川総合病院, 眼科, 教授 (40170930)
SATAKE Yoshiyuki 東京歯科大学市川総合病院, 眼科, 講師 (60385143)
YAMAGUCHI Takefumi 東京歯科大学市川総合病院, 眼科, 講師 (20383771)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 角膜移植 / 涙液サイトカイン / 移植免疫 |
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| Outline of Final Research Achievements |
Recently, not only “in part corneal transplantation” relevant to the pathophysiology of the underlying etiology but also the variability of the surgical procedures regarding the risks of complications relevant to the treatment policy is on demand. On that front, measurement and quantification of the postsurgical tear cytokines would help us in better understanding of the pathophysiological processes and in constructing the best treatment strategies.
The results of our initial experiments measuring the tear cytokines after Descemet’s Stripping Automated Endothelial Keratoplasty, showed that changes of the tear cytokines occurred not only in the operated eye but also contralateral eye. Some pro-inflammatory and anti-inflammatory cytokines had a peak in 1 month in the operated eyes showing a gradual increase within 3 months in the contralateral eyes. Successive scientific analysis necessitates a longer follow-up and comparative studies of different etiologies and surgical methodologies.
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| Free Research Field |
角膜移植
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