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2015 Fiscal Year Final Research Report

Effect of the corneal stem/progenitor cells during the corneal inflammatory cell infiltration

Research Project

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Project/Area Number 25861657
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionSt. Marianna University School of Medicine

Principal Investigator

Ueno Hiroki  聖マリアンナ医科大学, 医学部, 講師 (30529897)

Project Period (FY) 2013-04-01 – 2016-03-31
Keywords角膜stem/progenitor 細胞 / 角膜三叉神経 / 角膜Side population / 炎症細胞 / IL-1β / TNF-α
Outline of Final Research Achievements

Two corneal sutures were placed with 11-0 nylon between the mouse corneal center and the limbus to induce the inflammatory cell infiltration. As a result of determining the chronological change qualitatively and quantitatively, both corneal nerves and corneolimbal stem/progenitor cells are significantly reduced after infiltration of inflammatory cell. Therefore, the data suggest a critical role of inflammation in maintaining corneal stem/progenitor cells that formed the corneal stem cell niche and/or the corneal nerve.

Free Research Field

眼科

URL: 

Published: 2017-05-10  

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