2016 Fiscal Year Final Research Report
Genetic research of pathogenesis and prognosis in biliary atresia with DNA microarray
| Project/Area Number |
25861674
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatric surgery
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| Research Institution | Nagoya University (2014-2016)
Aichi Medical University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 胆道閉鎖症 / 遺伝子解析 / マイクロアレイ |
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| Outline of Final Research Achievements |
The purpose of the study was to further investigate the cause and pathology of biliary atresia, and analyzed changes in gene expression in liver tissues of biliary atresia closely and comprehensively using gene microarray.
Liver tissue obtained by surgery from a patient with biliary atresia and other diseases as a control were used. RNA was extracted from liver tissue and microarray was performed. From the gene expression profile, 60 genes were up-regulated and 39 genes were down-regulated in biliary atresia. GO analysis suggested that several biological pathways related to immune and inflammatory responses may be involved in the development of biliary atresia.
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| Free Research Field |
小児外科学
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