2016 Fiscal Year Final Research Report
Effect of Klotho gene on subcutaneous fat tissue and skin wound healing
| Project/Area Number |
25861692
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Kindai University (2016)
Sapporo Medical University (2013-2015) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 老化 / 病理学 / 免疫学 |
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| Outline of Final Research Achievements |
Expression of Adiponectin mRNA was not significantly different between wild type and klotho deficient mice. LPS-induced TNF-α production was not suppressed in the presence of Secreted α-klotho protein but was significantly increased in the presence of FGF23. Thus, FGF23 may have a function to promote TNF-α production independently of α-klotho protein. In klotho deficientl mice, excess production of TNF-α in wounds might cause delay in wound healing.
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| Free Research Field |
形成外科
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