2014 Fiscal Year Final Research Report
Analysis for the scar fomations assosiated MRTF-A
| Project/Area Number |
25861696
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 瘢痕 / ケロイド / MRTF-A |
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| Outline of Final Research Achievements |
Abnormal scar formations, for example, keloids and hypertrophic scars, are often caused by myofibroblasts. These cells contract the surrounding extracellular matrix resulting in the increased tissue density characteristic of scar tissue. However, its roles in abnormal scar formations are largely unknown. In this research, we showed that myocardin-related transcription factor-A (MRTF-A), a co-activator of serum response factor (SRF), mediates prohypertrophic signaling related between the scar formations and myofibroblasts. We used the methods by collagen gel contraction assay, stimulating MRTF inhibitor.
At the result, MRTF inhibitor suppressed the fibroblasts even if cell viability. However, our studies have expected the result to the potential therapeutic targets for the new treatment of abnormal scars.
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| Free Research Field |
形成外科
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