A novel therapy for sepsis targeted to the inflammasome

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861721
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Nagasaki University
• Principal Investigator: TAJIMA Goro 長崎大学, 病院(医学系), 助教 (00437427)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: インフラマソーム / 敗血症 / 自然免疫 / SIRS

Outline of Final Research Achievements

We aimed to develop a novel therapy of sepsis targeting for inflammasome, which is responsible for activation of inflammatory process in innate immune system. We measured activation of immune cells and inflammasome in murine sepsis model, and evaluated the effect of blocking inflammasome using blocking reagent of caspase-1. In murine sepsis model, immune cells showed increase of activation markers and inflammasome activation (caspase-1, NALP3), and innate immune receptors. Prior administration of inflammasome inhibitor reagent decreased the expression of activation markers and inflammasome activation, and increased the expression of innate immune receptors in immune cells.

Free Research Field

救急医学