Renal Nerve-Mediated Erythropoietin Release Confers Cardioprotection During Remote Ischemic Preconditioning.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861739
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Kurume University
• Principal Investigator: OBA TOYOHARU 久留米大学, 医学部, 助教 (10389257)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: サイトカイン / 心筋保護 / プレコンディショニング / 臓器連関 / β2刺激

Outline of Final Research Achievements

Screened circulating cardioprotective JAK-STAT-activating cytokines in mice unexpectedly revealed increased serum erythropoietin (EPO) levels after formoteol injection. In mice, RIPC rapidly upregulated EPO mRNA and its main transcriptional factor, hypoxia-inducible factor-1α (HIF1α), in the kidney. Formoteol activated cardio-protective signaling pathways such as STAT3, AKT, ERK in mice heart, and reduced infarct size calculated by Evans-blue TTC staining. These results suggest that the activation of the HIF1α-EPO course in the kidney might bring reduction of the myocardial infarct size after the Formoteol dosage.

Free Research Field

循環器内科