2014 Fiscal Year Final Research Report
Functional mapping of excitatory synaptic inputs in the agranular insular cortex
| Project/Area Number |
25861764
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 島皮質 / 局所神経回路 / uncaging |
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| Outline of Final Research Achievements |
The insular cortex (IC) plays a pivotal role in processing multiple sensory information. Laser-scanning photostimulation (LSPS) mapping using slice preparations is suitable for exploring neural connections to comprehend the source of excitatory synaptic inputs to a cell.In the present study, we focused on the excitatory synaptic inputs to layer 5 neurons in the AI, which are considered to involve principal projecting neurons to other brain areas. Both pyramidal cells and fast spiking interneurons in upper and middle layer 5 showed the largest evoked EPSCs by stimulating around the recording cell soma, and the evoked EPSC amplitude steeply decreased with increasing distance from the soma. In contrast, the fast-spiking interneurons recorded from lower layer 5 received potent excitatory inputs from ventral and lower directions in the AI.
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| Free Research Field |
神経生理
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