2015 Fiscal Year Final Research Report
Molecular biological analysis of disease developing mechanism of progressive condylar resorption
| Project/Area Number |
25861774
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 進行性下顎頭吸収 / 仮骨延長 / サイトカイン |
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| Outline of Final Research Achievements |
We investigated the influence of mechanical stress on the temporomandibular joint (TMJ) in a rabbit model. We divided the rabbits into 2 groups, traction and compressive, and compared them at each period.Tractional mechanical stress led to changes in the form of the condyle, including significantly reduced bone volume and decreased bone mineral density. In addition, the number of TRAP-positive cells was increased in the traction group during each period. Furthermore, subchondral bone formation disorders were more prominent in the traction group as compared to the compressive group.Our findings demonstrated that the TMJ may be more affected by tractional than compressive mechanical stress.Moreover, we speculate that condylar resorption is related to subchondral cells, though findings following immunohistochemical staining are needed as part of a future examination.
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| Free Research Field |
病態科学系歯学・歯科放射線学
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