Creation of root caries model for evaluation and development of antibacterial biomaterials

2016 Fiscal Year Final Research Report

• Project/Area Number: 25861784
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Tohoku University
• Principal Investigator: Mayanagi Gen 東北大学, 歯学研究科, 助教 (10451600)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: ISFET微小pH電極 / pH / エナメル質 / 象牙質 / 根面う蝕 / う蝕関連細菌 / 脱灰 / インターフェイス

Outline of Final Research Achievements

The mineral solubility of coronal enamel and root dentin were evaluated using a model of tooth/bacteria interface. The pH changes at the interface were measured by a miniature ion-sensitive field-effect transistor pH electrode and the amounts of calcium dissolved from tooth surfaces were measured by a fluorescent dye. As a result, it was suggested that root dentin is more soluble to the bacteria-induced acidification than coronal enamel, and that the minerals dissolved from tooth surfaces could raise pH at the tooth/bacteria interface. The method employed in the present study could be useful for evaluating the caries-preventive effects on tooth surface treatment.

Free Research Field

う蝕学