Induction of odonto-/osteoblastic differentiation by FGF18 and its clinical application

2016 Fiscal Year Final Research Report

• Project/Area Number: 25861787
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Ohi Chie 東京医科歯科大学, 歯学部, 非常勤講師 (30431935)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: FGF18 / FGFシグナル / 硬組織分化 / 歯髄幹細胞 / 骨芽細胞 / 分化誘導 / Akt

Outline of Final Research Achievements

Fibroblast growth factors (FGF)18 is a famous growth factor involved in development/differentiation of bone/cartilage tissues. This project focused on the effects of FGF18 on pulpal and osteoblastic differentiation. FGF18 promoted the cell growth of human dental pulp stem cells, mouse calvaria-derived osteoblasts, and mouse osteoblast-like cells: MC3T3-E1. It also enhanced alkaline phosphatase and DSPP mRNA expression. These results indicate that FGF18 possesses an ability to induce differentiation/maturation of hard-tissue forming cells. Clinical application of FGF18 may effectively induce differentiation/mineralization of odonotoblasts and osteoblasts.

Free Research Field

歯内療法学