Induction of enamel regeneration by cross-talk between Shh signaling and BMP/Wnt signaling

2016 Fiscal Year Final Research Report

• Project/Area Number: 25861791
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Takahashi Satomi 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (40451918)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: エナメル芽細胞 / Shh / Bmp / Wnt / シグナルネットワーク / 分化誘導

Outline of Final Research Achievements

Sonic hedgehog (Shh) is an essential factor for ameloblast differentiation, but crosstalk between Shh signaling and Wnt or BMP signaling may regulate the ameloblast differentiation. In this project, enhanced expression of Gli1, which is a major transcriptional factor of Shh signaling, induced increase of Wnt and BMP signals, and suppression of Wnt signaling blocked the mineralization of ameloblast-like cells (ALCs). These results suggest the importance of crosstalk among Shh, Wnt and BMPs in ameloblast differentiation.

Free Research Field

歯内療法学