2015 Fiscal Year Final Research Report
Role of multidrug efflux pumps on Porphyromonas gingivalis biofilm
| Project/Area Number |
25861798
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | バイオフィルム / 抗菌薬抵抗性 / 薬剤排出ポンプ |
|---|
| Outline of Final Research Achievements |
This study showed that Porphyromonas gingivalis, which is a major pathogen in marginal periodontitis and refractory periapical periodontitis, has several genes encoded a putative multidrug efflux pumps. However, two inhibitors of multidrug efflux pump, which were reported to inhibit multidrug efflux pumps in several bacterial species, didn't affect biofilm formation and sensitivity to erythromycin in P gingivalis.
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| Free Research Field |
歯科保存学
|
