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2014 Fiscal Year Final Research Report

Elucidation of the innate immune response of dental pulp cells against bacteria-derived factor in the pathogenesis of pulpitis

Research Project

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Project/Area Number 25861802
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Conservative dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

TAKEGAWA Daisuke  徳島大学, 大学病院, 助教 (10632664)

Project Period (FY) 2013-04-01 – 2015-03-31
Keywords歯髄炎 / 歯髄細胞 / 自然免疫 / インターフェロンγ
Outline of Final Research Achievements

In the progression of pulpitis, marked infiltration of inflammatory cells such as activated T cells producing interferon-γ (IFN-γ) is observed. Dental pulp cells have a capacity to produce various pro-inflammatory cytokines in response to caries-related bacteria via microbial pattern recognition receptors (PRRs). It is possible that IFN-γ can modulate pro-inflammatory response to PRRs ligands on the dental pulp cells. Indoleamine 2, 3-dioxygenase (IDO) is a regulator of immune responses and has been implicated in the progression of tumor tolerance, autoimmune disease and asthma. Although IDO expression is regulated and induced by IFN-γ in immune cells, IDO expression in dental pulp cells have not been reported.
This study demonstrated the synergistic effects by IFN-γ on IL-6 and CXCL10 production and expression of IDO in cultured human dental pulp cells. These findings suggest that IFN-γ may modulate the innate immune response of human dental pulp cells.

Free Research Field

歯科保存学

URL: 

Published: 2016-06-03  

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