2014 Fiscal Year Final Research Report
In vivo safety evaluation of novel radical disinfection technique –focusing on risk evaluation of carcinogenesis-
Project/Area Number |
25861820
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Prosthodontics/ Dental materials science and
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Research Institution | Tohoku University |
Principal Investigator |
HAYASHI Eisei 東北大学, 歯学研究科(研究院), 大学院非常勤講師 (60375102)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Keywords | ラジカル / 過酸化水素 / 殺菌 / オキシドール |
Outline of Final Research Achievements |
In the disinfection treatment with photolysis of hydrogen peroxide, stabilizers added in commercially available oxydol products, which had been expected to be used in the final disinfection device as a source of hydrogen peroxide, could be denatured. In addition to hydroxyl radical, such denatured components could be a risk factor of carcinogenesis. In the present study examining in vivo local toxicity and the effect of laser light irradiation on the stabilizers, the following results were obtained. That is, 1) the disinfection treatment did not show any in vivo toxicity in local mucosal tissues, 2) laser light irradiation of oxydol products made stabilizers denatured, and 3) 3% hydrogen peroxide solution without stabilizers was proven to be stable. These results suggest that short-term treatment of periodontitis using the disinfection technique would be free from a risk of carcinogenesis when stabilizer-free hydrogen peroxide solution is used.
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Free Research Field |
歯科補綴
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