The association between primary sleep bruxism and polymorphisms or epigenetical regulations

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861833
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Showa University (2014-2015); Tokyo Medical and Dental University (2013)
• Principal Investigator: Abe Yuka 昭和大学, 歯学部, 助教 (80614156)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 睡眠時ブラキシズム / SNP / 遺伝子多型 / セロトニン神経系

Outline of Final Research Achievements

The aim of study was to investigate the association between multifactorial primary sleep bruxism and polymorphisms or epigenetical regulations. A total of 29 individuals (F/M=16/13, mean age 26.4 ±2.8 y) participated after signing the university-approved consent form. Polysomnography and genotyping were conducted with these participants. The result showed that the individuals with rs6311 (-1438A/G) G allele in the promoter region of 5-HT 2A gene exhibited significantly more frequent tonic bursts during sleep (median: 1.43 times/hr, range 0-4.12, p=0.029). In order to approach serotonergic epigenetic regulation in the etiology of sleep bruxism, the animal study was performed. The experiment on mice suggested that selective serotonin uptake inhibitors (SSRIs) might affect the induced threshold level of masseter muscle activity during sleep.

Free Research Field

補綴歯科学、睡眠時ブラキシズム