2015 Fiscal Year Final Research Report
Study on effect of mastication for prevention of diabetes via GLP-1
| Project/Area Number |
25861860
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 咀嚼 / GLP-1 / 糖代謝 / 咬合 |
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| Outline of Final Research Achievements |
GLP-1 is synthesized in the intestine and has a function called incretin effect to lower levels of glucose in the blood. In this study, I built the hypothesis that mastication promotes GLP-1 by parasympathetic nerve, and we examined mastication affect secretion of GLP-1 and number of pancreatic beta-cells.
Active GLP-1 levels in rats that masticated solid feed, was higher than that in the rats that drank liquid feed. In case of intraperitoneal administration of atropine to block parasympathetic nerve , GLP-1 level in the both groups were approximately equal level. After breeding by solid feed or liquid feed for 3 months, pancreatic beta-cells in the solid feed group were observed more than that in the liquid feed group. In this study, it is suggests that mastication affects the secretion of GLP-1 via parasympathetic nerve and GLP-1 protects pancreatic beta-cells in rats.
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| Free Research Field |
歯科補綴学
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