2016 Fiscal Year Final Research Report
Development of a novel onlay bone graft technique utilized rhFGF-2 impregnated gelatin hydrogel GBR membrane
Project/Area Number |
25861882
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Dental engineering/Regenerative dentistry
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Noritake Kanako 東京医科歯科大学, 歯学部附属病院, 助教 (60624210)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Keywords | 骨造成 / GBR / 吸収性メンブレン / FGF-2 / FGF-18 |
Outline of Final Research Achievements |
A basic study for development of a novel bone graft technique which is effective not only bone neogenesis but also preventing mucosa dehiscence by utilizing rhFGF-2, which is effective for mucosa hyperplasty, impregnated GBR membrane installed at the surgical site. We also investigated the utility of FGF-18 and membrane combination because of it’s profitably to bone formation. First, the biocompatibility and its validity as a GBR membrane of improved gelatin hydrogel membrane containing β-tricalcium phosphate (G/T) was confirmed. Then, rhFGF-2 or rhFGF-18 impregnated G/Ts were installed between rat parietal bone or with silicon dome and the above periosteum to determine their effect to mucosa healing and bone neogenesis. Well-mucosa healing was observed at surgical site and newly-formed bone was observed at the space created by the G/T worked as a space keeper while worked as the carrier of FGFs.
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Free Research Field |
骨造成 デンタルインプラント
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