2014 Fiscal Year Final Research Report
Regeneration of jaw bone using sustained release system of statins; the mechanism of osteogenesis by statins
| Project/Area Number |
25861897
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
TANABE Koji 東京歯科大学, 歯学部, 助教 (80638156)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | スタチン / 骨再生 / 骨補填剤 / 骨 / 骨粗鬆症 |
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| Outline of Final Research Achievements |
The purpose of this study was to develop the new osteogenic drugs with the HMG-CoA reductase inhibitors.The fluvastatin-gelatin complex sponge was prepared and investigated in vitro. The results showed that a molecule of gelatin has coupling ability for a specific amount of fluvastatin. In addition, the fluvastatin-gelatin complex had the osteogenic activity through the inhibition of HMG-CoA reductase.
In animal experiment, the fluvastatin-gelatin complex sponge significantly enhanced osteogenic effect on low-turnover osteoporosis model mouse.
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| Free Research Field |
歯科医用工学・再生歯学
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