2014 Fiscal Year Final Research Report
Basic research for periodontal tissue regeneration type implant using periodontal ligament cells
| Project/Area Number |
25861901
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 歯周組織再生 / 歯根膜 / 象牙質 / 歯槽骨 / セメント質 / インプラント / 象牙芽細胞 / 歯髄 |
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| Outline of Final Research Achievements |
The purpose of this research was verifying the possibility of the periodontal ligament regeneration around the tooth implant.
In this study I revealed the following. (1) The ceria-stabilized tetragonal zirconia polycrystals/ aluminium oxide nanocomposite (Ce-TZP) has a same ability for bone induction compared to titanium. (2) In transplantation experiments of titanium implants to type 2 diabetes model rat. Nerve growth factor (NGF) was effective for bone induction to surrounding the implant. (3) The different of the two splice variants of porcine dentin sialophosphoprotein (DSPP) gene were revealed between dental pulp cells and odontoblasts. From this result, it showed that DSPP gene is useful as a differentiation marker of odontoblasts.
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| Free Research Field |
分子生化学
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