2015 Fiscal Year Final Research Report
Establishment of the pain control method by molecular delivery using ultrasound and nanobubbles
| Project/Area Number |
25861908
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
MATOBA ATSUKO (青井あつ子) 東北大学, 歯学研究科(研究院), 助教 (70547257)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 術後疼痛制御 / ナノバブル / 分子デリバリー / GDNF |
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| Outline of Final Research Achievements |
Introduction of GDNF plasmid using nanobubbles and ultrasound into plantar muscle in postoperative pain model rat with plantar incision influence guarding behavior and heat/mechanical hyperalgesia. Analgesic effects are observed.
However expression of pain-related cytokines and apoptosis of nerve cells are not changed. Further research will be necessary.
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| Free Research Field |
医歯薬学
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