Molecular mechanism of cancer stem cells to chemoradio resistance in human oral squamous cell carcinoma

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861909
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Tohoku University
• Principal Investigator: Taniguchi Takahiro 東北大学, 歯学研究科(研究院), 大学院非常勤講師 (40444012)
• Co-Investigator(Renkei-kenkyūsha): MIYASHITA Hitoshi 東北大学, 大学院歯学研究科, 助教 (70372323)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 癌幹細胞 / 扁平上皮癌 / 口腔腫瘍

Outline of Final Research Achievements

1. It has recently been reported that cancer stem cells (CSCs) is responsible for tumorigenesis, invasion, metstasis and chemo-radio resistance. We confirmed the increasing number of CSCs according to sphere formation in conditioned serum-free culture medium with epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF).
2. COX-2 was expressed in oral tumors, and significant positive correlation was found between Ki-67 and COX-2 expressions. It may contribute to local extensions
by increasing the proliferations of their odontogenic epithelial cells.

Free Research Field

口腔外科