2015 Fiscal Year Final Research Report
The mechanism of late lymph node metastasis in oral squamous cell carcinoma.
| Project/Area Number |
25861915
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Toho University (2014-2015)
Tokyo Medical and Dental University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 口腔癌 / 原発巣 / 頸部リンパ節転移巣 / 相同性 / 相違性 / SNPsアレイ |
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| Outline of Final Research Achievements |
We compared the genetic profile of paired primary tumor (PT) and metastatic lymph node (MLN) samples obtained from patients with oral tongue squamous cell carcinoma (OTSCC). Large-scale genetic profiling was performed on paired PT-MLN samples obtained from 10 OTSCC patients using high-density single-nucleotide polymorphism microarrays. We compared the genetic profile of PT and MLN OTSCC samples to identify common and specific copy number alterations (CNAs) and copy-neutral loss-of-heterozygosity (CN-LOH). This study indicates that additional genetic changes, such as 20q11.2 gain, which encodes the E2F1 gene, can be acquired through clonal evolution, and may be required for the metastatic process.
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| Free Research Field |
口腔癌
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