Establishment of mandibular distraction using drug controlled release-related living body absorption membrane and FGF-2, marrow stem cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861917
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: HIGUCHI YUSUKE 東京医科歯科大学, 歯学部附属病院, 医員 (20635536)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 骨延長 / メンブレン / FGF-2 / 骨髄幹細胞 / 吸収性人工骨

Outline of Final Research Achievements

This study was designed to evaluate the effect of drug controlled release-related living body absorption membrane and FGF-2, marrow stem in rabbit mandibular distraction. Peripheral quantitative computed tomographic analysis, von Kossa staining, and calcein staining showed significantly increased cortical bone mineraldensity, also had a significantly larger number of cells and radiopaque areas were observed morefrequently. The present findings suggested that the combined use of drug controlled release-related living body absorption membrane and FGF-2, marrow stem cells reduced the treatment period for distraction osteogenesis and accelerated the formation of a new high-quality bone.

Free Research Field

外科系歯学