2015 Fiscal Year Final Research Report
Functional analysis of lamina propriae as a cancer stroma in the oral mucosal carcinoma in situ.
| Project/Area Number |
25861920
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 口腔粘膜上皮内癌 / 血管 / リンパ管 / 粘膜固有層 / 線維化 |
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| Outline of Final Research Achievements |
To evaluate the possibility of tumor stroma in lamina propriae of carcinoma in situ (CIS), the distribution of lymphatics and blood vessels, oral submucous fibrosis, the expression of extracellular matrix were investigated in CIS, normal epithelium, epithelial dysplasia and squamous cell carcinoma (SCC). Lymphatics in CIS were characterized by their closed lumen, irregular shapes. The distribution mode of closed and irregular shaped lymphatics in the peripheral invasive front of SCC resembled those of CIS. In CIS, the elastic fiber were irregularly formed and aggregated, and muscle fiber were denatured sporadically with slightly immunopositive stain due to the submucous fibrosis.
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| Free Research Field |
口腔癌
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