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2014 Fiscal Year Final Research Report

Development of the molecular target therapy that assumed oral cancer stem cell a target

Research Project

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Project/Area Number 25861929
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

HAMADA Masakazu  大阪大学, 歯学研究科(研究院), 招へい教員 (80506361)

Project Period (FY) 2013-04-01 – 2015-03-31
Keywords癌幹細胞 / 分子標的治療
Outline of Final Research Achievements

Recent advances in a molecular target therapy are remarkable. However the molecular target therapy for oral cancer is delayed. So it is important to study new molecular target, such as cancer stem cell, which have resistance for cancer treatment and is the cause of any recurrence. We isolated CD44(+) cells as cancer stem cell marker, the formation of sphere cells could be observed. Antioxidant prevent the apoptosis of oral SCC cells by safingol. These results suggest that H2O2 is involved in the nuclear translocation of the mitochondrial factor of endo G. Endo G may be useful as a molecular target in cases of oral SCC.

Free Research Field

口腔癌

URL: 

Published: 2016-06-03  

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