2014 Fiscal Year Final Research Report
Research of the regulation of carcinoma by inhibition of nuclear receptor pathway.
| Project/Area Number |
25861931
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
TOMOTAKE Masuda 大阪大学, 歯学研究科(研究院), 招へい教員 (20510978)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 核内受容体 / 扁平上皮癌 / FABP4 / 増殖 / 浸潤 / 転移 |
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| Outline of Final Research Achievements |
We have reported that PPARgamma is highly expressed in human oral squamous cell carcinoma, and regulate the pathway of FABP4. In this study, we found FABP4 is ectopically expressed on tumor cells in oral squamous cell carcinoma. Knockdown of FABP4 by siRNA in cultured cell lines of Squamous cell carcinoma dramatically suppressed the cellgrowth.
These results imply a potentially important and novel role for the inhibition of FABP4 function in the treatment of squamous cell carcinoma and the preventeion of tumor invasion and metastasis.
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| Free Research Field |
口腔外科学
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