2014 Fiscal Year Final Research Report
Analysys of cytokine-induced EMT in oral squamous cell carcinoma cells.
| Project/Area Number |
25861941
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
OKUI gaku 広島大学, 大学病院, 歯科診療医 (00646888)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 上皮間葉移行 / 口腔扁平上皮癌 |
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| Outline of Final Research Achievements |
Present study demonstrated that a Snail/Slug-dependent EMT program with parallel signaling that provides polarized cell motility via AKT is required to execute EMT . Our model will contribute to the basic understanding of how varied environmental conditions at a given stage in the cancer life cycle (e.g., stroma invasion vs. nest formation) may induce phenotypic changes (e.g., induction of EMT) in SCC cells, even if the EMT master regulator Snail is constitutively expressed at a high level.
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| Free Research Field |
口腔癌
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