2014 Fiscal Year Final Research Report
The Bone Regenerative effect of Osteoblasts on Novel Hydroxyapatite Ceramics and Basic Study for Clinical application
| Project/Area Number |
25861944
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
TADA MISATO 広島大学, 大学病院, 歯科診療医 (40572326)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 多孔質セラミックス / ハイドロキシアパタイト / 骨芽細胞 / 骨再建材料 |
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| Outline of Final Research Achievements |
IP-CHA (Interconnected Porous Calcium Hydroxyapatite) is an excellent ceramic for use in bone tissue engineering because of its fully interconnected porous structure, which allows osteoblasts dispersion and supports their osteogenic differentiation. This study provided biochemical evidence that the IP-CHA/osteoblasts composite and IP-CHA/osteoblasts/TGF-β1 (Transforming growth factor-β1) composite could enhance osteogenic potential. It was strongly suggested that IP-CHA was a useful biomaterial for bone tissue regeneration.
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| Free Research Field |
口腔外科学
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