2015 Fiscal Year Final Research Report
Identification of new predictive factor for combined chemotherapy with docetaxel against oral cancer
| Project/Area Number |
25861949
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | docetaxel / resistance / predictive factor / oral cancer |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the molecular mechanism of docetaxel resistance in oral squamous cell carcinoma (OSCC) by using docetaxel resistant OSCC cell lines. Microarray analysis revealed that the expression of receptor transporter protein 3 (RTP3) only was elevated in all three docetaxel-resistant cell lines. Western blot analysis confirmed increased expression of RTP3 protein in docetaxel-resistant cells compared with the parental cell lines. Furthermore, immunohistochemical staining showed that, positive staining for RTP3 is correlated with chemoresistance to docetaxel-based chemotherapy in 40 OSCC patients and the poor outcome of the patients who received docetaxel-based chemotherapy. These results suggest that RTP3 might have great potential for predicting the efficacy of docetaxel-based chemotherapy against OSCC.
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| Free Research Field |
歯科口腔外科
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