2014 Fiscal Year Final Research Report
Molecular cytogenetic study of chromosomal amplification in oral cancer
| Project/Area Number |
25861950
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 癌 / ゲノム / 細胞・組織 |
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| Outline of Final Research Achievements |
The aim of this study is to investigate the biological role of chromosomal amplification in chromosome 8, and 11 and to clarify the genes canditating with amplification of these chromosomal region with over-expression in oral squamous cell carcinoma (OSCC). We comprehensively screened gene expression of 16 genes in 11q13 and 8 genes in 8q24.3. Three genes were identified as candidate gene in 11q13 and no gene associated in 8q24.3. The gene amplification correlated with the over-expression in 1 of 3 genes in 11q13. Amplification of this gene was observed in 13 of 50 OSCC cases. This result suggests that the gene relates with the development of OSCC.
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| Free Research Field |
外科系歯科学
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