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2014 Fiscal Year Final Research Report

Targeting oncomiR in oral squamous cell carcinoma

Research Project

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Project/Area Number 25861952
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionEhime University

Principal Investigator

TANAKA Hiroshi  愛媛大学, 医学部附属病院, 医員 (80647371)

Project Period (FY) 2013-04-01 – 2015-03-31
Keywords口腔癌 / microRNA
Outline of Final Research Achievements

We assessed the growth inhibitory effect of LNA ASO for miR-361-3p in vivo using a mouse model. But there was no significant difference compared to the control group. It did not also observed side effects such as weight loss and loss of appetite in mice. LNA ASO was transfected into primary cultured cells at the concentration of 10 nM. As in the case of OSCC cell lines, knockdown of miR-361-3p induced the growth inhibition of OSCC primary cultured cells.
Furthermore, bioinformatic and microarray analyses indicated that miR-361-3p and miR-133ab could target OSR2 mRNA and CEBPA mRNA.

Free Research Field

口腔癌

URL: 

Published: 2016-06-03  

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