Selective hyperthermia using magnetic anti-cancer compound for neck metastasis of oral squamous cell carcinoma

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861964
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Yokohama City University
• Principal Investigator: IIDA Masaki 横浜市立大学, 附属病院, 指導診療医 (70613511)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 口腔癌 / ハイパーサーミア / 新規磁性抗癌剤 / 頸部リンパ節転移

Outline of Final Research Achievements

Patients of oral squamous cell carcinoma with bulky or multiple cervical lymph node metastases have a poor prognosis. Our strategy for these patients is the chemoradiotherapy using superselective intra-arterial infusion combined with hyperthermia. On the other hand, we developed new compound for magnet-guided delivery with anti-cancer activity named EI236. This compound has a magnetic property, so it can be used for thermochemotherapy. This study was to evaluate the anti-cancer efficacy of this new drug. We evaluated the combined two-fold strategy, i.e., chemotherapy with EI236 and alternating magnetic field induced heating of this drug to induce local hyperthermia, in both cultured cancer cells and cancer-bearing nude mouse. We found this new drug is effective as anti-cancer agent in both cultured cancer cells and mouse model of tongue cancer, and that alternating magnetic field exposure enhanced the anti-cancer effect.

Free Research Field

口腔癌