• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2015 Fiscal Year Final Research Report

Evaluation of the taste disorder generation mechanism and development of the cure with anticancer drugs.

Research Project

  • PDF
Project/Area Number 25861968
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionNara Medical University

Principal Investigator

Aoki Kumiko  奈良県立医科大学, 医学部, 助教 (40448767)

Project Period (FY) 2013-04-01 – 2016-03-31
Keywords味覚障害 / 抗癌剤
Outline of Final Research Achievements

Although taste disorders are frequently observed in cancer patients undergoing chemotherapy, generation mechanism is unknown. The aim of the study was to reveal generation mechanism of taste disorders. In S-1 administered rats, no morphologic changes in mucosal epithelia basal cells and taste buds were observed. Immunohistochemical staining for a neuronal marker, PGP 9.5, detected nerve fibers in the epithelium and subepithelium of the taste bud. And degeneration of taste cells in the ganglia was significantly increased. The taste disorders by the anticancer drug administration do not generate from the impairment of mucosal epithelia and taste bud, but possibility from neuropathy of the gustatory nerve.

Free Research Field

医歯薬学

URL: 

Published: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi