2014 Fiscal Year Final Research Report
Leptin Promotes Wound Healing in the Skin and Oral Moucosa
| Project/Area Number |
25861984
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
IDE Shinji 鶴見大学, 歯学部, 助手 (00611998)
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| Research Collaborator |
SATOMURA Kazuhito
TOKUYAMA Reiko
TADOKORO Susumu
UMEKI Hirochika
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | レプチン / 創傷治癒 / 皮膚 / 口腔粘膜 |
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| Outline of Final Research Achievements |
Leptin, a 16 kDa anti-obesity hormone, exhibits various physiological properties. Interestingly, skin wound healing was proven to delay in leptin-deficient ob/ob mice. However, little is known on the mechanisms of this phenomenon. In this study, we attempted to elucidate a role of leptin in wound healing of skin and oral mucosa.
Topically administered leptin was proven to promote wound healing in the skin by accelerating proliferation, differentiation/function and migration of epidermal keratinocytes and enhancing angiogenesis around the wounded area. These results strongly suggest that topical administration of leptin may be useful as a treatment to promote wound healing in the skin.
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| Free Research Field |
口腔外科、口腔内科
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